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Pipeline C - Memory impairment

  • Spontaneous alternation in the Y-maze – spatial working memory
  • Social Discrimination test – social recognition memory, olfactory memory
  • Object Recognition test – object recognition memory
  • IntelliCage – spatial learning and memory, reversal learning, reward learning
  • Olfactory discrimination – olfactory learning and function: sensitivity, discriminatory abilities, long-term olfactory memory
  • Neurogenesis rate – assessment of adult neurogenesis in brain hippocampus, olfactory bulb and rostral migratory stream using different neurogenesis markers; deficits are related to memory impairments
  • Pharmacologic challenge – possibility to validate behavioural alterations by influencing them through application of relevant pharmacological agents, e.g. specific compounds to enhance memory or specific receptor ligands