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GMC - German Mouse Clinic

GMC

German Mouse Clinic

GMC - German Mouse Clinic

GMC

German Mouse Clinic

24.09.2019

News regarding the claudin family member 12 and blood-brain barrier integrity

In a collaborative study, scientists from the University of Bern and the German Mouse Clinic investigated the impact of the claudin family member 12...

09.07.2019

New rationale for NOX4/5 inhibitors for neuroprotective strategy after stroke

Ischemic stroke is a predominant cause of disability worldwide. The thrombolytic or mechanical occlusion has to be removed immediately to supply the...

25.02.2019

Novel finding: Mutation in the X-linked Ftsj1 gene caused not only intellectual disability in mice and men, but affects also additional organ systems

Intellectual disability (ID) is a major developmental disorder and currently it was estimated to affect around 1% of the population at average. The...

04.02.2019

Sea squirt alternative oxidase prevents lethal mitochondrial cardiomyopathy in a mouse model of GRACILE syndrome

Scientists from the Folkhälsan Research Center in Helsinki, Finland, the German Mouse Clinic and colleagues from Sweden investigated, whether the...

18.12.2018

Cataract causing mutations in the betaB2 crystallin led to schizophrenia phenotypes in mice

The beta crystallin gene (CRYBB2) is an ocular structural gene and mutation in this gene can cause cataract. Interestingly, beyond its role in the eye...

Phenotype your mouse model

GMC I: 

  1. Systemic, comprehensive phenotyping in 14 different disease areas
  2. Customized primary phenotypic screening in specific areas of interest (e.g. behavior, neurology and neuropathology)

GMC II: 

  1. Hypothesis-driven phenotypic analysis using environmental challenges
  2. Combining environmental challenges

GMCIII:

  1. Systemic analysis of compounds and drugs

View results of mutant lines

View the results of mutant mouse lines in the GMC phenomap.

How primary mouse phenotyping leads to novel insights for human health

Mouse phenotyping helps to better understand human diseases. Read more how systemic primary screening of mouse mutants uncovers unexpected new gene functions.

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The GMC Consortium

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